Color-changing contact lens shows when drugs are working

Contact lenses that change color after releasing drugs into the eye could help doctors determine whether a medication is being delivered to its intended treatment site. (c) American Chemical Society

Drugs designed to treat eye conditions are often delivered via eye drops. However, most of the time, the actual drug ends up dripping off the eye. That makes it difficult to tell how much of the medication is actually getting to the eye. Now in a study appearing in ACS Applied Materials & Interfaces, scientists from the Southeast University and China Pharmaceutical University, Nanjing, China, report that they have developed a contact lens that changes color as drugs are released. This visual indicator could help eye doctors and patients readily determine whether these medications are where they should be.

Eyes are adept at keeping things out. When something ventures into or toward an eye, the lids blink and tears start rapidly flowing to avoid infection and damage from foreign objects. These processes are usually helpful, but they can hinder the uptake of much-needed medications. Studies suggest that less than five percent of drugs in eye drops and ointments are absorbed. In addition, much of the absorbed medication ends up in the bloodstream instead of the eye, causing side effects. Contact lenses may be a more effective way to deliver drugs directly to the eye, but real-time monitoring of drug release is still a challenge. So Dawei Deng and Zhouying Xie sought to create a drug-delivering contact lens that would change color as the medication is released into the eye.

The researchers fabricated a color-sensitive contact lens using molecular imprinting. That technique creates molecular cavities in a polymer structure that match the size and shape of a specific compound, such as a medicine. In laboratory experiments, the molecularly imprinted contact lenses were loaded with timolol, a drug used to treat glaucoma. Then, the team exposed the lenses to a solution of artificial tears, which was used as a stand-in for the eye. As the drug was released from the contacts, the architecture of the molecules near the drug changed, which also changed the color in the iris area of the lenses. No dye was involved in the process, reducing possible side effects. The researchers could see this shift with the naked eye and with a fiber optic spectrometer. They conclude this new lens could control and indicate the sustained release of many ophthalmic drugs.

Source: American Chemical Society