A new cell phone app and lab kit now allow a smartphone to identify bacteria from patients anywhere in the world. With the new app “BactiCount” , doctors will be able to diagnose diseases and prescribe the appropriate antibiotic within a one-hour office visit, meaning faster recovery — and lower treatment costs — for patients.

Developed by a research team of UC Santa Barbara scientists and colleagues, the detection system succeeded in achieving rapid diagnosis of urinary tract infections — among the most common type of infection globally. The app uses a smartphone’s camera to measure a chemical reaction and determines a diagnosis in about an hour — and the simple, low-cost test can be performed in the world’s most remote locations.

“This simple test for urinary tract infections can be conducted in a fraction of the time and cost of clinical diagnostics — one hour versus 18 to 28 hours,” Professor Michael Mahan of UC Santa Barbara explained. “We believe that this lab test holds exciting potential to bring state-of-the-art diagnostics within easy reach of non-expert users.”

The process is simple and straightforward. A small volume of the patient’s urine sample is collected and analyzed by BactiCount using the phone’s camera and the diagnostic kit. No additional specialty materials are required. “This is a great example of an interdisciplinary collaboration between biologists and engineers to solve important biomedical problems,” said Tom Soh of Stanford University. “We hope technologies like this offer new ways of providing better healthcare around the globe.”

Urine samples are collected and a custom-built app uses a smartphone’s camera to measure a chemical reaction and determines a diagnosis in about an hour. (c) Courtesy of UC Santa Barbara

Interdisciplinary cooperation

The multi-institution collaboration was launched to develop rapid, low-cost diagnostics that can be used by healthcare providers anywhere in the world to diagnose bacterial infections. The test can be performed rapidly and the lab kit can be produced for less than $100. And it requires little more than a smartphone, a hot plate, LED lights and a cardboard box. “Urinary tract infections are particularly harmful to pregnant women and can cause miscarriage,” explained Lynn Fitzgibbons, M.D., an infectious disease physician at Santa Barbara Cottage Hospital. “Thus, there is a medical need for rapid, low-cost, on-site testing — particularly in resource-limited settings.”

The simple lab test works on a variety of pathogens and diverse patient specimens (blood, urine and feces), enabling clinical utility for a number of infectious diseases. Additionally, the test can be modified to detect emerging pathogens that pose an ongoing threat to human health. “The app enables early-stage diagnosis and intervention, which is particularly important in the context of multidrug-resistant pathogens for which treatment options are highly limited,” said Jeff Fried, a clinical care physician at Santa Barbara Cottage Hospital. “Such early treatment also reduces the risk of the emergence of multidrug-resistant pathogens.”

Source: UC Santa Barbara